The inhibitor concentration to IC50 ratios for the two pairs of ITZ stereoisomers, calculated using peak and trough concentrations of the two enantiomeric pairs after a single dose administration (day 1) of a 100-mg oral solution of itraconazole and after multiple dose administration (100 mg/day) for 7 days
Day 1 | Day 7 | |||||
|---|---|---|---|---|---|---|
| Cmax/IC50 | Cmin/IC50 | Cmax/IC50 | Cmin/IC50 | |||
| 2R,4S-ITZ | 23.4 | 0.6 | 130 | 12.1 | ||
| 2S,4R-ITZ | 23.4 | 2.0 | 63.9 | 15.7 | ||