P450 | Form-Selective Activity | Inhibition Type | Apparent Ki Value | Predicted Inhibition of P450 in Vivo |
---|---|---|---|---|
μM | % | |||
CYP2C9 | Diclofenac 4′-hydroxylation | Competitive | 82 ± 10 | 2 |
CYP2C19 | S-Mephenytoin 4′-hydroxylation | Competitive | 7.2 ± 0.9 | 21 |
CYP2D6 | Bufuralol 1′-hydroxylation | Noncompetitive | 41 ± 4 | 4 |
CYP3A | Midazolam 1′-hydroxylation | Competitive | 13 ± 2 | 13 |
CYP3A | Testosterone 6β-hydroxylation | Noncompetitive | 56 ± 4 | 3 |