Decision criteria for teratogenic potency rating of VPA derivatives investigated in the NMRI-exencephaly-mouse model (Nau, 1981)
Teratogenic Potency | Dose Range | Exencephaly Rate | Description |
|---|---|---|---|
| mmol/kg | % | ||
| 0 | >3.00 | 0 | No teratogenic potency detectable |
| + | 2.00-3.00 | 1-5 | Low teratogenic potency |
| ++ | 2.00-3.00 | 5-25 | Lower teratogenic potency than VPA |
| +++ | 2.00-3.00 | 25-60 | Equal teratogenic potency to VPA |
| ++++ | 1.00-2.00 | 40-60 | Higher teratogenic potency than VPA |
| +++++ | 0.25-1.00 | 40-60 | Very high teratogenic potency |