Pharmacokinetic parameters of S-2-pentyl-4-pentynoic hydroxamic acid, its metabolite S-2-pentyl-4-pentynoic acid, and valproic acid ( Radatz et al., 1998 ) in the NMRI mouse model
S-2-Pentyl-4-pentynoic Hydroxamic Acid X | S-2-Pentyl-4-pentynoic Acid IX | Valproic Acid I | |
|---|---|---|---|
| Dosage (mmol/kg) | 0.80 | 1.50 | 3.00 |
| Cmax (μg/ml) | 230 | 630 | 730 |
| tmax (μg/ml) | 15 | 30 | 15 |
| t1/2 (h) | 0.33 | 4.24 | 1.40 |
| AUC0→∞ (h · μg/ml) | 100 | 3443 | 1748 |
| Vz (l/kg) | 0.733 | 0.454 | |
| CL (ml/h/kg) | 1466 | 67 | |
| Mean residence time (h) | 0.54 | 6.22 |
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