Reproducibility of CYP3A inhibition by mulberry juice
Values are presented as mean ± S.D. of triplicate assays. The amount of fruit juice used in assays was 12.5 μl (5.0%, v/v). The control activity of midazolam 1′-hydroxylation by human liver microsomes determined in the absence of fruit juice was 3.65 nmol min–1 mg–1 protein.
Purchase Date of Mulberry Juice | Residual Activity |
|---|---|
| % | |
| April 9, 2005 | 40.0 ± 1.9 |
| June 18, 2005 | 39.0 ± 3.8 |
| August 13, 2005 | 40.9 ± 3.1 |
| October 15, 2005 | 36.6 ± 5.2 |