Animal No. | Clearances | Morphine Metabolized | Metabolic Clearance | Placental Clearance Morphine | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
M3Ga | M6Gb | Morphinec | M3G | M6G | M3G | M6G | ||||||
ml · min-1 | % | ml · min-1 | ml · min-1 | |||||||||
240 | 150 ± 24 | |||||||||||
248 | 2.0 ± 0.22d | 83 ± 9.6 | 31 | 25 | 58 | |||||||
278 | 1.7 ± 0.10 | 97 ± 10 | 32 | 31 | 66 | |||||||
290 | 2.8 ± 0.09 | 87 ± 11 | 35 | 30 | 57 | |||||||
292 | 2.4 ± 0.10 | 83 ± 9.3 | 38 | 32 | 51 | |||||||
294 | 2.1 ± 0.06 | 73 ± 1.8 | 28 | 20 | 53 | |||||||
297 | 1.6 ± 0.28 | 72 | 36 | 26 | 46 | |||||||
319 | 62 ± 19 | |||||||||||
322 | 79 ± 8.4 | |||||||||||
327 | 2.4 ± 0.10 | 2.8 | 140 ± 33 | 33 | 1.2 | 46 | 1.6 | 92 | ||||
331 | 2.1 ± 0.30 | 2.0 | 54 ± 6.6 | 27 | 0.85 | 15 | 0.48 | 39 | ||||
342 | 1.9 ± 0.17 | 1.0 | 65 ± 15 | 33 | 0.67 | 21 | 0.46 | 44 | ||||
Mean ± S.D. | 2.1 ± 0.39 | 1.9 ± 0.91 | 87 ± 29 | 32 ± 3.5 | 0.90 ± 9.0 | 27 ± 9.0 | 0.84 ± 0.63 | 56 ± 15 |
↵ a M3G clearances from initial series of M3G infusions.
↵ b M6G clearances corrected for simultaneous infusion of morphine (see Materials and Methods).
↵ c For morphine clearances, from samples obtained during venous infusion and before administration of any induction agent.
↵ d M3G clearance from a previous study was not included in overall mean but was used for calculation of metabolic clearance.