TABLE 5

Statistical parameters for changes in metabolism and total clearance with gestational age

For comparative purposes, change is presented as percent change per day, determined by dividing the slope of the individual regression lines by the mean parameter value for individual animals × 100. Overall changes are determined from the regression lines of the mean parameter values and mean gestational age during venous infusion for each animal as drawn in Fig. 5.

Animal
Infusion Route
Clearance
M3G Ratio
M6G Ratio
% change · day-1
r2
 % change · day-1
r2
 % change · day-1
r2
240 Venous -5.9 0.74 -3.8 0.76 -11 0.60
248 Venous 1.1 0.30 -3.2 0.58* -2.0 0.22
278 Venous 2.9 0.75 2.5 0.52 1.6 0.10
Arterial -7.7 0.56 -13 0.55 -11 0.78
290 Venous -0.53 0.07 0.27 0.03 -3.0 0.45
292 Venous 0.06 0.00 1.2 0.08 -0.9 0.07
319 Venous 11 0.99* 18 0.84* 20 0.97*
Arterial 0.69 0.06 1.6 0.22 0.09 0.00
322 Venous 1.6 0.57* -0.66 0.08 0.20 0.00
327 Venous 1.0 0.06 2.0 0.14 5.5 0.52*
331 Venous 1.2 0.09 -1.4 0.06 -6.7 0.89*
342 Venous 4.9 0.65* 2.2 0.23 3.4 0.16
Overall
Venous
0.25
0.00
-1.0
0.02
-0.20
0.00

  • ↵* p < 0.05.