TABLE 1

Bile flow and CDF recovery at 60 min in bile and perfusate of single-pass perfused livers from wild-type, Abcg2-/-, and Abcc2-/- mice

Wild-Type
Abcg2-/-
Abcc2-/-
Average bile flow (μl/min/g liver) 0.82 ± 0.07 0.98 ± 0.04* 0.48 ± 0.20*
CDF excretion (% of dose)
    Bile 47 ± 15 65 ± 6* 0.027 ± 0.023*
    Perfusate 35 ± 11 32 ± 3 90 ± 8*
    Total
82 ± 9
97 ± 5*
90 ± 8

  • Data represent the mean ± S.D. of three to six experiments.

  • ↵* p < 0.05 compared with wild-type mice.