Recovery of radioactivity in urine, feces and bile during the 0 to 24-h collection period after a single oral dose of [14C]muraglitazar to mice (data were obtained with pooled samples from each group)
Group | Dose | Recovery of Radioactivity | ||||||
|---|---|---|---|---|---|---|---|---|
| Urine | Feces | Bile | Total | |||||
| mg/kg | % dose | |||||||
| 1M (intact mice) | 1 | 6.85 | 80.5 | 87.4 | ||||
| 2M (intact mice) | 40 | 13.4 | 81.3 | 94.7 | ||||
| 3M (BDC mice) | 1 | 8.26 | 8.17 | 74.8 | 91.2 | |||
| 4M (BDC mice) | 40 | 16.1 | 11.9 | 65.7 | 93.7 | |||