Metabolite | Rt (min) | MH+ | Major MS/MS Fragmentsa (ranked by intensity) | Proposed Identity |
---|---|---|---|---|
P | 63.24 | 517 | 186, 192 | Muraglitazar |
M1 | 18.46 | 332 | 137, 107 | O-Dealkyl muraglitazar |
M2 | 22.04 | 519 | 308, 465, 483, 343, 187 | 8-Hydroxy-O-demethyl muraglitazar |
M3 | 22.81 | 549 | 324, 187 | 8,12-Dihydroxy muraglitazar |
M4 | 24.67 | 549 | 306, 425, 324, 187 | 9,12-Dihydroxy muraglitazar |
M5 | 25.28 | 519 | 290, 395, 447, 184 | 12-Hydroxy-O-demethyl muraglitazar |
M6 | 27.43 | 519 | 202, 308 | 17-Hydroxy-O-demethyl muraglitazar |
M7 | 29.29 | 519 | 290, 202, 187 | 9-Hydroxy-O-demethyl muraglitazar |
M8a | 31.09 | 533 | 308, 202, 187 | 8-Hydroxy muraglitazar |
M8 | 32.42 | 549 | 306, 218, 324, 202 | 12,17-Dihydroxy muraglitazar |
M9 | 34.18 | 507 | 529 (Na) to 282, 176 | Imide derivative of muraglitazar |
M10 | 36.21 | 533 | 409, 290, 187, 308, 205 | 12-Hydroxy muraglitazar |
M11 | 39.31 | 533 | 202, 308 | 17-Hydroxy muraglitazar |
M12 | 40.97 | 547 | 322, 216 | Muraglitazar 12-carboxylic acid |
M13a | 39.98 | 693 | 292, 621, 557, 517 | Acyl glucuronide of muraglitazar |
M13b | 41.28 | 693 | 517, 292 | Acyl glucuronide of muraglitazar |
M13c | 43.23 | 693 | 292, 657, 613 | Acyl glucuronide of muraglitazar |
M13d | 43.96 | 693 | 292, 657, 613, 583, 499 | Acyl glucuronide of muraglitazar |
M14 | 42.56 | 533 | 202, 290, 308, 187 | 9-Hydroxy muraglitazar |
M15 | 44.87 | 503 | 186, 292 | O-Demethyl muraglitazar |
M16 | 50.23 | 549 | 594 (CH3CH2NH2) to 282, 176, 220 | N-Acetyl imide derivative of muraglitazar |
M17a | 20.79 | 695 | 519, 290 | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M17b | 21.26 | 695 | 519, 221 | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M17c | 22.75 | 695 | 659, 519, 290, 264, 308, 202 | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M17d | 24.26 | 695 | 519, 659, 637 | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M17e | 24.67 | 695 | 519 | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M17f | 25.08 | 695 | 519, 637, 558, 222 | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M17g | 26.2 | 695 | 519, 308, 202 | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M17 h | 27.84 | 695 | 519, 202 | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M17i | 28.41 | 695 | 659, 519, | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M17j | 28.8 | 695 | 558, 659, 519 | Acyl glucuronide of hydroxy-O-desmethyl muraglitazar |
M18a | 23.35 | 709 | 533 | Acyl glucuronide of hydroxy muraglitazar |
M18b | 24.56 | 709 | 484, 378, 533, 308, 202 | Ether glucuronide of hydroxy muraglitazar |
M18c | 26.35 | 709 | 533, 290, 673, 307, 202 | Acyl glucuronide of hydroxy muraglitazar |
M18d | 27.95 | 709 | 308, 673, 202, 290 | Acyl glucuronide of hydroxy muraglitazar |
M18e | 28.47 | 709 | 308, 202, 629, 673, 292 | Acyl glucuronide of hydroxy muraglitazar |
M18f | 29.96 | 709 | 290, 673, 202 | Acyl glucuronide of hydroxy muraglitazar |
M18g | 30.52 | 709 | 673, 290, 533, 202 | Acyl glucuronide of hydroxy muraglitazar |
M20a | 28.62 | 679 | 292, 503 | Acyl glucuronide of O-demethyl muraglitazar |
M20b | 30.99 | 679 | 292, 503, 643 | Acyl glucuronide of O-demethyl muraglitazar |
M20c | 39.78 | 679 | 292, 413, 621, 503, 263 | Acyl glucuronide of O-demethyl muraglitazar |
M20d | 40.3 | 679 | 292, 413, 503 | Acyl glucuronide of O-demethyl muraglitazar |
M20e | 41.07 | 679 | 292, 643, 413 | Acyl glucuronide of O-demethyl muraglitazar |
M21 | 8.43 | 318 | 221, 177, 133, 199 | O-Dealkyl-O-desmethyl muraglitazar |
M24 | 35.57 | 624 | 292, 186, 416, 499, 471, 542 | Taurine conjugate of muraglitazar |
M25 | 26.66 | 610 | 292, 186, 355 | Taurine conjugate of O-demethyl muraglitazar |
M26a | 19.74 | 640 | 308,519, 265 | Taurine conjugate of hydroxy muraglitazar |
M26b | 22.55 | 640 | 290,464, 308, 187 | Taurine conjugate of hydroxy muraglitazar |
M26c | 25.53 | 640 | 290, 202 | Taurine conjugate of hydroxy muraglitazar |
M26d | 27.02 | 640 | 432, 515, 292, 280, 186 | Taurine conjugate of hydroxy muraglitazar |
M26e | 23.4 | 640 | 202, 308, 464, 432 | Taurine conjugate of hydroxy muraglitazar |
M27 | 25.89 | 537 | 206, 312, 238,188 | Reduction of hydration derivative of muraglitazar |
M28 | 32.78 | 535 | 204, 310, 186, 238 | Hydration derivative of muraglitazar |
M29a | 13.78 | 856 | 820, 515, 709, 290, 691, 595, 533, 409 | Glutathione adduct of dihydroxy muraglitazar |
M29b | 15.86 | 856 | 709, 533, 290, 820, 691, 613 | Glutathione adduct of dihydroxy muraglitazar |
M30 | 18.4 | 840 | 308, 693, 597, 711, 468, 765 | Glutathione adduct of hydroxy muraglitazar |
M31 | 18.98 | 656 | 306, 218 | Taurine conjugate of dihydroxy muraglitazar |
M32 | 27.69 | 549 | 218, 306, 187 | Dihydroxy muraglitazar |
M33 | 53.86 | 533 | 186, 308 | Hydroxy muraglitazar |
M34 | 64.7 | 515 | 262, 290, 187 | 8-Ene muraglitazar |
M35 | 47.6 | 533 | 308, 264, 186 | Hydroxy muraglitazar |
↵ a Major fragment ions for M9 and M16 were from their sodium or CH3CH2NH2 adduct ions, respectively. These adduct ions instead of their MH+ were the predominant species for these two metabolites.