AUCs of pimecrolimus and its metabolites in blood
Healthy male subjects treated with a single oral dose of 15 mg of [3H]pimecrolimus. Data are derived from metabolite patterns (examples in Fig. 3, A and B); mean ± S.D. of n = 4.
Radioactivity | Pimecrolimus | Metabolite Dx_1 | Highly Polar Metabolites (Front-Peak) | Sum of Additional Trace Metabolites | |
|---|---|---|---|---|---|
| AUC0-24 h (pmol · h/ml) | 387 ± 81 | 189 ± 50 | 18 ± 7 | 35 ± 8 | 144 ± 30 |
| AUC0-24 h (%) | 100 | 49 | 5 | 9 | 37 |