TABLE 2

The parameters of eight model compounds in rats

Compound	Class	In Vivo K_p	f_u,plasma	f_u,homogenate	f_u,slice	C_slice/C_plasma	f_u,plasma/f_u,slice	f_u,plasma/f_u,homogenate
Caffeine	Neutral	0.70^a	0.96 ± 0.03	1.1 ± 0.2	0.71	0.36	1.3	0.87
CP-141938	Base	0.31^a	0.56 ± 0.01	0.22 ± 0.03	0.11	2.8	5.0	2.5
Fluoxetine	Base	25^a	0.060 ± 0.001	0.00094 ± 0.00050	0.0027	20	22	60
NFPS	Zwitterion	0.90^a	0.041 ± 0.005	0.0017 ± 0.0002	0.011	2.7	3.7	24
Propranolol	Base	15^a	0.15 ± 0.02	0.036 ± 0.009	0.019	8.4	7.9	4.2
Quinidine	Base	0.5^b	0.184 ± 0.023	0.0392 ± 0.0035	0.032	6.1	5.8	4.7
Theobromine	Neutral	0.50^a	0.92 ± 0.06	0.61 ± 0.09	0.62	1.6	1.5	1.5
Theophylline	Neutral	0.31^a	0.29 ± 0.01	0.39 ± 0.06	0.31	0.60	0.94	0.74

↵ a Liu et al., 2005.
↵ b Kusuhara et al., 1997.