TABLE 3

The parameters of thirteen model compounds in mice

Compound	K_p,wt	K_p,ko	K_p,ko/K_p,wt	C_slice/C_plasma	f_u,plasma/f_u,homogenate
Caffeine	1.0^a	1.1^a	1.1	0.78	2.2^c
CP-141938	0.10^b	5.0^b	50	2.6	N.A.
Fluoxetine	12^a	18^a	1.5	10	14
NFPS	0.84	1.6	2.0	2.2	N.A.
Propranolol	17	26	1.5	13	N.A.
Quinidine	0.30^a	10^a	36	5.2	N.A.
Theobromine	0.60	0.84	1.5	1.8	N.A.
Theophylline	0.73	0.92	1.3	1.3	N.A.
Midazolam	0.20^a	0.20^a	1.0	1.8	1.7^c
9-OH Risperidone	0.10^a	1.0^a	17	1.7	3.8^c
Sulpiride	0.078^a	0.20^a	1.9	1.4	1.2^c
Thiopental	0.40^a	0.40^a	1.2	1.0	2.1^c
Zolpidem	0.29^a	0.40^a	1.4	2.9	1.2^c