Pharmacokinetic parameters of melagatran after oral administration of ximelagatran alone (day 1) and in combination with erythromycin (day 6)
Parameter | Ximelagatran Alone (n = 15) | Ximelagatran + Erythromycin (n = 15) | Treatment Comparison Day 6/Day 1 | |
|---|---|---|---|---|
| AUC (μmol · h/l) | Mean (S.D.) | 1.52 (0.42) | 2.76 (0.81) | 1.82 (1.64, 2.01)a |
| Median (range) | 1.39 (0.975-2.35) | 2.51 (1.66-4.89) | 1.93 (1.02, 2.42) | |
| Cmax (μmol/l) | Mean (S.D.) | 0.25 (0.06) | 0.44 (0.11) | 1.74 (1.52, 2.00)a |
| Median (range) | 0.25 (0.15-0.35) | 0.47 (0.22-0.69) | 1.85 (0.81, 2.42) | |
| tmax (h) | Mean (S.D.) | 2.2 (0.7) | 2.5 (0.7) | N.E. |
| Median (range) | 2.0 (1.5-3.0) | 3.0 (1.5-4.0) | 1.0 (0.5, 2.0) | |
| t (h) | Mean (S.D.) | 3.2 (0.3) | 3.0 (0.4) | N.E. |
|
| Median (range) | 3.1 (2.9-4.0) | 2.9 (2.5-3.7) | 0.9 (0.8, 1.2) |
N.E., not estimated.
↵ a Least-squares mean estimates (90% CI) for between-treatment comparison (day 6/day 1).