Condition | Papp, A-Ba (× 10-6 cm/s) | Papp, B-Ab (× 10-6 cm/s) | Efflux Ratioc (Papp, B-A/Papp, A-B) |
---|---|---|---|
MDCK-MDR1 Cells | |||
Ximelagatran alone (50 μM) | 1.2 (0.2) | 39 (3.7) | 33 |
+ Quinidine (100 μM) | 4.9 (0.2) | 7.0 (0.6) | 1.4 |
+ Erythromycin (500 μM) | 5.3 (0.1) | 12 (1.0) | 2.3 |
[3H]Digoxin (27 nM) | 2.0 (0.2) | 37 (0.7) | 19 |
MDCK-WT Cells | |||
Ximelagatran alone (50 μM) | 5.9, 5.2 | 15 (1.5) | 2.7 |
+ Quinidine (100 μM) | 6.7 (1.7) | 5.9 (0.3) | 0.9 |
+ Erythromycin (500 μM) | 7.6 (1.7) | 9.9 (3.7) | 1.3 |
[3H]Digoxin (27 nM) | 5.8 (0.8) | 24 (9) | 4.1 |