Calculated pharmacokinetic parameters of TPA023 after a single oral 3-mg (99-μCi) dose of [14C]TPA023
Subject No. | Cmax | Tmax | t1/2 | AUC0-∞ |
|---|---|---|---|---|
| ng/ml | h | h | ng · h/ml | |
| 007 | 32.8 | 2.0 | 5.2 | 238.8 |
| 008 | 26.5 | 2.0 | 10.4 | 339.1 |
| 009 | 29.3 | 2.0 | 6.9 | 277.3 |
| 010 | 29.1 | 2.0 | 5.3 | 241.8 |
| 011 | 24.5 | 2.0 | 5.5 | 187.2 |
| Mean | 28 | 2.0 | 6.7 | 257 |
| S.D. | 3.0 | 0.0 | 2.2 | 56 |
| CV (%) | 11.0 | 0.0 | 33.2 | 21.8 |