Rates of formation of OH-MXC and HPTE in hepatic microsomes and OH-MXC in intestinal microsomes from control, methoxychlor-treated, and 3-MC-treated channel catfish Values shown are pmol/min/mg protein and are mean ± S.D., n = 4 fish per treatment group. Fish were treated as described in Table 1.
Treatment Group | Livera | Intestineb OH-MXC | ||
|---|---|---|---|---|
| OH-MXC | HPTE | |||
| Control | 120 ± 45 | 6 ± 5 | 32 ± 3.9 | |
| Methoxychlor-treated | 87 ± 18 | N.D. | 15 ± 6d | |
| 3-MC-treated | 200 ± 6c | 15 ± 4d | 72 ± 22d | |
N.D., formation of HPTE was below detection levels (<0.5 pmol/min/mg protein) in most samples
↵ a Incubations were carried out with 25 μM methoxychlor
↵ b Incubations were carried out with 15 μM methoxychlor
↵ c Significantly different from control, p < 0.05
↵ d Significantly different from control, p < 0.01