Ketoconazole, clotrimazole, and α-naphthoflavone IC50 values (μM) for inhibition of OH-MXC formation from 25 μM methoxychlor in hepatic microsomes from control, methoxychlor-treated, and 3-MC-treated channel catfish Values are mean ± S.D., n = 4 fish per treatment group.
Treatment Group | Ketoconazole | Clotrimazole | α-Naphthoflavone |
|---|---|---|---|
| Control | 5.5 ± 3.9 | 1.7 ± 1.3 | 102 ± 9 |
| Methoxychlor-treated | 5.9 ± 3.0 | N.D. | 98 ± 12 |
| 3-MC-treated | 3.4 ± 0.4 | 1.6 ± 1.8 | 80 ± 8a |
N.D., not determined
↵ a Significantly different from control, p < 0.05