Average receptor occupancies in the brain and liver after intratracheal instillation of triamcinolone acetonide phosphate (2.5, 25, and 50 μg/kg) in neonatal rats and TA (100 μg/kg) in adult rats
Dose | Number of Independent Experiments | Average Receptor Occupancy | Ratio | |||
|---|---|---|---|---|---|---|
| Liver | Brain | Brain vs. Liver | ||||
| μg/kg | % | |||||
| Neonatal rats | 2.5 | 4 | 17.4 ± 13.5 | –14.7 ± 11.9 | N.D. | |
| 25 | 3 | 45.3 ± 7.8 | 45.7 ± 9.7 | 1.10 ± 0.14 | ||
| 50 | 4 | 50.8 ± 13 | 47.0 ± 9.6 | 0.87 ± 0.13 | ||
| Adult rats | 100 | 3 | 55.3 ± 8 | 11.4 ± 6.7 | 0.21 ± 0.14 | |
N.D., not determined