TABLE 1

Summary of microdialysis probe recovery rate in the five-step infusion and DPHM-PRN coadministration experiments Data are shown as mean ± S.D.




Step 1

Step 2

Step 3

Step 4

Step 5

DPHM-PRN
CSFa probe (%) 46.3 ± 4.0 48.0 ± 2.6 46.1 ± 3.8 45.8 ± 2.7 43.3 ± 3.5 44.5 ± 4.0
ECFa probe (%)
47.9 ± 4.0
47.4 ± 2.7
46.2 ± 2.3
44.8 ± 3.6
45.4 ± 3.9
44.0 ± 3.4b
  • a Probe recovery rates were determined using eq. 1

  • b n = 3 because of failure of ECF probes in three of the animals. Otherwise, n = 6