TABLE 2

Ratio of metabolic activities in liver and intestine slices from rat and mouse Substrates (100 μM; testosterone, triazolam, quinidine, lidocaine, carbamazepine, verapamil, and midazolam) were incubated for 3 h with liver and intestinal slices from rat and mouse. Results are ratios from means of individual slices (three separate experiments, n = 3 slices each).


Metabolites Measured

Activity Ratio Liver/Intestine
Rat
Mouse
Androstenedione 1.5 8.3
MEGX 1.7 4.3
6β-TOH 3.4 2.3
16α-TOH 5.5 11
16β-TOH 0.1 4.8
Nor-verapamil 0.9 0.8
3-OH-Quinidine 0.3 1.1
1-OH-Triazolam 1.4 0.8
4-OH-Midazolam 2.2 1.8
1-OH-Midazolam 0.7 1.7
Carbamazepine epoxide
6.6
5.8