Predicted mean in vivo LTG AUC ratios calculated from Ki values generated in the absence and presence of BSA
In vitro Ki | Predicted AUC Ratio Based on | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| [I]max | [I]max.unbound | [I]ave | [I]ave.unbound | [I]inlet.max | [I]inlet.max.unbound | [I]inlet.ave | [I]inlet.ave.unbound | |||||||||
| μM | ||||||||||||||||
| Without BSA | ||||||||||||||||
| Mean | 2465 | 1.22 | 1.02 | 1.17 | 1.00 | 1.28 | 1.03 | 1.23 | 1.02 | |||||||
| S.D. | 370 | 0.03 | 0.01 | 0.03 | 0.00 | 0.04 | 0.00 | 0.03 | 0.00 | |||||||
| Range | 1988–2987 | 1.18–1.26 | 1.01–1.02 | 1.14–1.20 | 1.00–1.00 | 1.23–1.34 | 1.02–1.04 | 1.19–1.28 | 1.02–1.03 | |||||||
| With BSA | ||||||||||||||||
| Mean | 387 | 2.08 | 1.10 | 1.86 | 1.01 | 2.31 | 1.18 | 2.12 | 1.15 | |||||||
| S.D. | 12 | 0.05 | 0.01 | 0.04 | 0.00 | 0.05 | 0.01 | 0.05 | 0.01 | |||||||
| Range | 361–430 | 1.99–2.13 | 1.09–1.11 | 1.79–1.91 | 1.01–1.01 | 2.21–2.37 | 1.16–1.19 | 2.04–2.18 | 1.13–1.16 | |||||||