TABLE 1

Mean derived kinetic parameters for LTG N2-glucuronidation by human liver microsomes, with and without BSA

Hill Component
Michaelis-Menten Component
S50
Vmax1
 n
Km
Vmax2
μM pmol/min/mg μM pmol/min/mg
Without BSA
   Mean 1869 162 0.65 2234 594
   S.D. 1286 108 0.16 774 333
   Range 748–3999 82–346 0.56–0.87 1487–3435 347–1158
With BSA
   Mean 255 99 0.59 2342 694
   S.D. 170 46 0.16 1118 299
   Range
102–504
63–177
0.41–0.80
1217–3614
289–1085