Fold induction of control rat P450 genes following administration of the prototypical P450 inducers BNF, PB, DEX, and CLO Mean ± S.E.M. of three male Sprague-Dawley rat livers expressed to two significant figures.
Gene | Mean Fold Induction of Control ± S.E.M. | ||||||
|---|---|---|---|---|---|---|---|
| BNF (80 mg/kg/day) | PB (80 mg/kg/day) | DEX (150 mg/kg/day) | CLO (200 mg/kg/day) | ||||
| CYP1A1 | 2500 ± 520 | 0.83 ± 0.66 | 1.7 ± 0.62 | 0.78 ± 0.22 | |||
| CYP1A2 | 23 ± 4.3 | 0.70 ± 0.11 | 0.18 ± 0.018 | 0.54 ± 0.12 | |||
| CYP2B1 | 1.3 ± 0.12 | 680 ± 110 | 49 ± 13 | 3.1 ± 0.82 | |||
| CYP2B2 | 0.82 ± 0.23 | 22 ± 2.3 | 50 ± 2.6 | 22 ± 3.7 | |||
| CYP2E1 | 0.91 ± 0.12 | 0.60 ± 0.24 | 0.64 ± 0.052 | 1.5 ± 0.13 | |||
| CYP3A2 | 1.9 ± 0.28 | 2.4 ± 0.98 | 7.4 ± 0.26 | 2.7 ± 0.33 | |||
| CYP3A23 | 1.0 ± 0.23 | 4.9 ± 0.33 | 59 ± 12 | 1.2 ± 0.15 | |||
|
CYP4A1
| 1.2 ± 0.37 | 0.44 ± 0.14 | 0.78 ± 0.11 | 16 ± 2.4 | |||