Haplotypes inferred from CYP3A4 and CYP3A5 genotype data and their frequencies
New | CYP3A Allele | Nucleotide Changes in Gene | Frequency % | ||
|---|---|---|---|---|---|
| Entire Group | Caucasian | ||||
| CYP3A4*1A | None | 20.3 | 18.8 | ||
| √ | CYP3A4*I | -392 a>g, 15753 t>g, 15977 c>t, 20230 g>a | 2.8 | 1.0 | |
| √ | CYP3A4*V | 15977 c>t, 20230 g>a, 22545 g>a | 5.6 | 5.2 | |
| √ | CYP3A4*VI | 15977 c>t | 53.7 | 59.4 | |
| √ | CYP3A4*XI | -392 a>g, 15753 t>g, 20230 g>a, 22545 g>a | 4.6 | 4.2 | |
| √ | CYP3A4*XIV | 20230 g>a, 22545 g>a | 4.6 | 4.2 | |
| √ | CYP3A4*XV | -392 a>g, 15753 t>g, 15977 c>t | 1.9 | 2.1 | |
| CYP3A5*1A | None | 5.6 | 4.2 | ||
| √ | CYP3A5*1F | 27526 c>t | 7.4 | 5.2 | |
| CYP3A5*3A | 6986 a>g, 31611 c>t | 77.8 | 78.1 | ||
| CYP3A5*3E | 6986 a>g, 27050 a>g, 31611 c>t | 8.3 | 9.4 | ||
| √ | CYP3A5*3U | 6986 a>g, 27050 a>g | 1.0 | 1.0 | |