Values used in simulation for model parameters not estimated
Model Parameter | Typical Value | Interstudy Variability (CV) |
|---|---|---|
| % | ||
| KTZ plasma fu | 0.01 | 10 |
| KTZ Keff (h-1) | 5 | 30 |
| KTZ Ki (μ M) | 0.0147 | 10 |
| KTZ mol. wt. (g/mol/1000) | 0.531 | —a |
| KTZ F (total bioavailability) | 1.0 | —a |
| KTZ Vmax (mg/l) | 41.1 | 30 |
| MDZ fm | 0.9 | 30 |
| MDZ plasma/blood partitioning | 0.86 | —a |
| MDZ blood fu | 0.04 | 10 |
| Hepatic blood flow (Qh) | male = 3.6 · weight0.75 female = male · 1.1 | |
| Portal vein blood flow (Qpv) | Qh · 0.75 | —a |
| Age | 32; 18; 65b | 10c |
| Body weight | 70; 40; 120b | 15c |