The Ki values of cyclosporin A, gemfibrozil, and gemfibrozil-1-O-glucuronide for the PSnet and PSapical of pitavastatin in double-transfected cells
The values are expressed as mean ± computer-calculated S.D.
Transfectants | Cyclosporin A | Gemfibrozil | Gemfibrozil-1-O-glucuronide |
|---|---|---|---|
| PSnet (Ki, μM) | |||
| OATP1B1/BCRP | 0.194 ± 0.048 | >100 | >100 |
| OATP1B1/MDR1 | 0.359 ± 0.046 | >100 | >100 |
| OATP1B1/MRP2 | 0.407 ± 0.132 | >100 | >100 |
| PSapical (Ki, μM) | |||
| OATP1B1/BCRP | 0.273 ± 0.083 | >300 | >300 |
| OATP1B1/MDR1 | 0.330 ± 0.037 | >300 | >300 |
| OATP1B1/MRP2 | 0.662 ± 0.252 | >300 | >300 |