TABLE 1

Kinetic parameters for haloperidol pyridinium metabolites HPP⁺and RHPP⁺in the hOCT1, 2, and 3 stably expressed MDCK cells

V_max represents the maximal reaction velocity, and K_m is the substrate concentration corresponding to 50% of V_max. The values are estimated from nonlinear least regression analysis using WinNonlin.