TABLE 1

Kinetic parameters of the uptake of valsartan by OATP1B1- and OATP1B3-expressing HEK293 cells

Data shown in Fig. 2 were used to determine these parameters calculated by nonlinear regression analysis as described under Materials and Methods. Each parameter represents the mean ± computer-calculated S.D.




Km

Vmax

Pdif
μM pmol/min/mg protein ml/min/mg protein
OATP1B1 1.39 ± 0.24 3.85 ± 0.46 0.747 ± 0.022
OATP1B3
18.2 ± 5.9
135 ± 40
0.680 ± 0.223