Uptake clearance of reference compounds (E1S and CCK-8) and valsartan in expression systems and human hepatocytes
Transporter-Expressing Cells | Human Hepatocytes | |||||||
|---|---|---|---|---|---|---|---|---|
| CLOATP1B1 | CLOATP1B3 | OCF | 094 | 03-013 | ||||
| μl/min/mg protein | μl/min/106 cells | |||||||
| E1S | 84.6 | 93.0 | 98.7 | 45.2 | ||||
| CCK-8 | 10.3 | 17.7 | 71.6 | 3.65 | ||||
| valsartan | 1.56 | 0.96 | 3.55 | 17.1 | 6.15 | |||