TABLE 3

Contribution of OATP1B1 and OATP1B3 to the hepatic uptake of valsartan in each batch of human hepatocytes

In the column `Estimated Clearance of Valsartan,' the lower row shows the percentage of OATP1B1- or OATP1B3-mediated uptake clearance relative to the sum of the estimated clearance mediated by OATP1B1 and OATP1B3. The details of this estimation are described under Materials and Methods.


Lot

Ratio of Uptake Clearance CLhep/CLtransporter

Estimated Clearance of Valsartan
Ract,OATP1B1
Ract,OATP1B3
OATP1B1
OATP1B3
μl/min/106 cells
OCF 1.10 1.72 1.72 1.65
51.0% 49.0%
094 1.17 6.95 1.83 6.67
21.5% 78.5%
03-013 0.53 0.35 0.827 0.336



71.1%
28.9%