Contribution of OATP1B1 and OATP1B3 to the hepatic uptake of valsartan in each batch of human hepatocytes
In the column `Estimated Clearance of Valsartan,' the lower row shows the percentage of OATP1B1- or OATP1B3-mediated uptake clearance relative to the sum of the estimated clearance mediated by OATP1B1 and OATP1B3. The details of this estimation are described under Materials and Methods.
Lot | Ratio of Uptake Clearance CLhep/CLtransporter | Estimated Clearance of Valsartan | ||||
|---|---|---|---|---|---|---|
| Ract,OATP1B1 | Ract,OATP1B3 | OATP1B1 | OATP1B3 | |||
| μl/min/106 cells | ||||||
| OCF | 1.10 | 1.72 | 1.72 | 1.65 | ||
| 51.0% | 49.0% | |||||
| 094 | 1.17 | 6.95 | 1.83 | 6.67 | ||
| 21.5% | 78.5% | |||||
| 03-013 | 0.53 | 0.35 | 0.827 | 0.336 | ||
|
|
|
| 71.1% | 28.9% | ||