TABLE 4

Kinetic parameters of the transcellular transport of valsartan in OATP1B1/MRP2 double transfectant

Data shown in Fig. 6 were used to determine these parameters calculated by nonlinear regression analysis as described under Materials and Methods. Each parameter represents the mean ± computer-calculated S.D.




Km

Vmax

Pdif
μM pmol/min/mg protein ml/min/mg protein
Transcellular transport 27.5 ± 4.1 164 ± 24 0.937 ± 0.123
PS apical
99.0 ± 51.1
461 ± 275
0.120 ± 0.610