TABLE 5

Summary for the pharmacokinetic parameters of valsartan in SD rats and EHBRs

Pharmacokinetic parameters are expressed as mean ± S.E. (n = 3).




AUC0-∞

V1

CLp

Liver Concentration

CLbile
μg · min/ml ml/kg ml/min/kg ng/g liver ml/min/kg
SD rat 58.9 ± 9.1 76.3 ± 7.0 17.8 ± 2.5 1.41 ± 0.22 12.5 ± 1.0
EHBR
991 ± 32**
49.0 ± 0.8*
1.01 ± 0.03**
3.45 ± 0.19**
0.283 ± 0.010**
  • * P < 0.05, ** P < 0.01.