TABLE 4

Effects of RIF on the intestinal microsomal metabolism of ATV (0.1 μM)

Data are mean values ± S.D. (n = 3)

RIF Concentrations
ATV Concentrationsa
% of control
0 μM 100.0 ± 7.4
10 μM 101.9 ± 1.8
20 μM 110.9 ± 6.6
35 μM 112.2 ± 8.5
50 μM
118.3 ± 5.6**

  • ↵** p < 0.01; significantly different from ATV-alone control.

  • ↵ a ATV concentrations at the end of a 15-min microsomal incubation study.