No b5 | Exogenous b5 (3:1 Ratio) | Coexpressed b5 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CYP3A4 | CYP3A5 | p Value | CYP3A4 | CYP3A5 | p Value | CYP3A4 | CYP3A5 | p Value | |||||||
V max | 0.90 ± 0.06 | 8.1 ± 0.4 | <0.0001 | 1.49 ± 0.07 | 11.0 ± 1.0 | <0.0001 | 2.97 ± 0.17 | 21.5 ± 0.9 | <0.0001 | ||||||
K m | 19.7 ± 3.0 | 14.3 ± 1.7 | 0.14 | 25.7 ± 2.6 | 13.3 ± 3.2 | 0.009 | 19.9 ± 2.5 | 16.7 ± 1.6 | 0.30 | ||||||
CLint | 0.046 ± 0.004 | 0.57 ± 0.04 | <0.0001 | 0.058 ± 0.003 | 0.83 ± 0.13 | <0.0001 | 0.15 ± 0.01 | 1.29 ± 0.08 | <0.0001 |