TABLE 1

mRNA expression level of OATP-B, OATP-D, OATP-E, and villin in human jejunal biopsy sample and Caco-2 cells examined by quantitative real-time PCR analysis


Subject No.

mRNA Expression Level (copy/ng total RNA)

Ratio
OATP-B
OATP-D
OATP-E
Villin
OATP-B/Villin
1 120 29 3.5 500 0.24
2 327 100 14.6 942 0.35
3 317 112 10.0 544 0.58
4 254 83 5.9 746 0.34
5 406 73 6.8 795 0.51
6 207 46 3.2 462 0.45
7 414 74 6.4 545 0.76
9 469 73 9.5 838 0.56
10 164 41 8.1 564 0.29
11 239 112 9.7 751 0.32
12 183 62 9.5 563 0.33
13 102 77 9.0 750 0.14
14 751 74 12.0 597 1.26
Mean 304 74* 8.3* 661 0.47
S.D. (n = 13) 177 25 3.2 149 0.29
Caco-2 cells (mean, n = 2)
9,030
34.9
154
925
9.76
  • * Significantly different from OATP-B (p < 0.05).