TABLE 1

AUC of total measurements (intracellular and incubation media) and intracellular measurements of ERY and N-demethyl-ERY

Data are depicted as the mean ± S.D., n = 3. Mass balances were determined. AUC ratios of N-demethyl-ERY to ERY (Met/ERY ratio) were also calculated.

AUC
ERY only
ERY + rifampin
ERY + GG918
μm · min
Total measurement (Cell and Media) of ERY and N-demethyl-ERY
    ERY 92.5 ± 4.6 96.2 ± 3.7 90.4 ± 3.3
    N-demethyl-ERY 7.63 ± 0.31 5.65 ± 0.24* 8.92 ± 0.62*
    Mass balance (%) 100 ± 5 101 ± 4 99.3 ± 3.5
Intracellular measurement of ERY and N-demethyl-ERY
    ERY 5.13 ± 0.33 3.96 ± 0.22* 6.67 ± 0.30*
    N-demethyl-ERY 0.795 ± 0.057 0.513 ± 0.028* 2.14 ± 0.21**
    Met/ERY ratio
0.155 ± 0.021
0.129 ± 0.025
0.320 ± 0.035*

  • ↵* p < 0.05, ** p < 0.01, significantly different from ERY only.