Dose | AUC0-∞ | CLp | Vdss |
t 1/2 |
μM · h | ml/min/kg | l/kg | h | |
i.v. | ||||
Rats (n = 4) | ||||
0.5 mg/kg | 0.9 ± 0.1 | 20.3 ± 1.0 | 10.6 ± 0.6 | 6.8 ± 0.7 |
Dogs (n = 3) | ||||
0.5 mg/kg | 6.2 ± 1.4 | 3.1 ± 0.7 | 2.0 ± 0.2 | 10.0 ± 0.2 |
| AUC0-∞ |
C
max
|
T
max
| F |
μM · h | μM | h | % | |
Oral | ||||
Rats (n = 4) | ||||
1 mg/kg | 1.5 ± 0.5 | 0.1 ± 0.0 | 5.0 ± 1.2 | 83 |
Dogs (n = 3) | ||||
1 mg/kg | 10.7 ± 3.3 | 1.0 ± 0.3 | 2.0 ± 0.0 | 86a |
↵ a Bioavailability of 1 mg/kg dose in dogs was determined individually for each dog in a crossover experiment with the same dogs dosed intravenously at 0.5 mg/kg.