Tissue-to-blood partition coefficient (RT) of FTY720 calculated from AUC ratios
Organ | Intravenous Doses | ||
|---|---|---|---|
| 0.3 mg/kg | 2 mg/kg | ||
| Lungs | 89.9 | 68.2 | |
| Heart | 27.7 | 17.4 | |
| Brain | 53.4 | 49.2 | |
| Kidneys | 53.7 | 35.8 | |
| Thymus | 19.6 | 19.6 | |
| Spleen | 67.4 | 62.1 | |
| Liver | 83.0 | 47.0 | |
| Muscle | 9.4 | 10.5 | |
| Lymph nodesa | 28.6 | 32.6 | |
↵ a Pool of mesenteric, axillary, inguinal, cervical, and popliteal lymph nodes.