Parameter | TM | SFM | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
(I) | (II) | (III) | (I) | (II) | (III) | |||||
fQ | —a | — | — | 0.06 ± 0.01 | 0.12 ± 0.10 | 0.20 ± 0.71 | ||||
Intrinsic Clearance (ml/min) | ||||||||||
CL1 | 5.8 ± 3.1 | 5.8 ± 3.5 | 2.8 ± 0.7 | 4.6 ± 4.3 | 5.4 ± 7.0 | 14.9 ± 379 | ||||
CL2 | 1.0 ± 0.7 | 1.0 ± 0.8 | 1.9 ± 3.9 | 0.90 ± 0.93 | 1.1 ± 1.6 | 15.0 ± 404 | ||||
CL3 | — | — | 0.028 ± 0.012 | — | — | 0.027 ± 0.009 | ||||
CL4 | — | — | 0.0093 ± 0.0026 | — | — | 0.011 ± 0.005 | ||||
CL5 (Control)b | 0.067 ± 0.017 | 2.3 ± 38.7 | 53.1 ± 771 | 52.0 ± 978 | 12.3 ± 158 | 32.4 ± 439 | ||||
CL5 (PCN)c | 0.17 ± 0.03 | 6.5 ± 0.0 | 126 ± 1833 | 71.4 ± 1341 | 16.9 ± 217 | 79.7 ± 1076 | ||||
CL6 | 0.0058 ± 0.0013 | 0.0070 ± 0.0017 | 4.6 ± 66.2 | 2.4 ± 46.1 | 2.8 ± 186 | 1.7 ± 20.9 | ||||
CL7 | 0.016 ± 0.008 | 0.015 ± 0.008 | 0.053 ± 0.113 | 0.020 ± 0.017 | 0.031 ± 0.023 | 0.082 ± 0.173 | ||||
CL9 | — | 0.83 ± 0.73 | — | — | 0.26 ± 0.20 | — | ||||
CL10 | — | 25.9 ± 425 | — | — | 0.052 ± 3.5 | — | ||||
CLg | 0.031 ± 0.011 | 0.034 ± 107 | 0.049 ± 0.016 | 0.030 ± 0.013 | 0.030 ± 0.013 | 0.054 ± 0.022 | ||||
r 2 | 0.999 | 0.999 | 0.999 | 0.997 | 0.998 | 0.999 | ||||
MSC | 6.28 | 6.22 | 6.40 | 5.60 | 5.58 | 6.40 | ||||
F test | N.S. (0.23) | S (5.95) | N.S. (-29.33) | N.S. (-9.13) | S (4.75) | |||||
SSR | 196 | 194 | 164 | 372 | 360 | 158 |
N.S., insignificantly different from TM(I) model at P = 0.05 (calculated F value included in parentheses); S, significantly different from TM(I) model at P = 0.05 (calculated F value included in parentheses).
↵ a —, not applicable.
↵ b Obtained from simultaneous fitting of systemic and intraluminal data of control.
↵ c Obtained from simultaneous fitting of systemic and intraluminal data of PCN treatment. All other CL values were fitted from both control and PCN-treated data.