TABLE 6

Summary statistics of population variation in the ABCB4 and ABCB11 genes


Gene

Population

SNP Type

bp Screened

n

Variable Sites*

θ (×10-4 ± S.D.)

π (×10-4 ± S.D.)

D
ABCB4 CA All 16797 128 40 4.39 ± 1.21 2.79 ± 1.52 -1.11
Noncoding 12960 128 31 4.41 ± 1.27 2.69 ± 1.53 -1.16
Coding 3837 128 9 4.32 ± 1.72 3.14 ± 2.24 -0.66
Intron 7434 128 14 3.47 ± 1.20 1.94 ± 1.32 -1.17
5′-UTR 5526 128 17 5.67 ± 1.87 3.70 ± 2.31 -0.95
JA All 16797 94 40 4.66 ± 1.34 4.20 ± 2.20 -0.31
Noncoding 12960 94 34 5.13 ± 1.51 4.83 ± 2.56 -0.18
Coding 3837 94 6 3.06 ± 1.42 2.07 ± 1.68 -0.73
Intron 7434 94 11 2.89 ± 1.10 2.76 ± 1.73 -0.12
5′-UTR 5526 94 23 8.98 ± 2.57 7.62 ± 4.23 -0.19
KO All 16797 96 43 4.98 ± 1.41 4.31 ± 2.26 -0.43
Noncoding 12960 96 38 5.71 ± 1.65 4.64 ± 2.47 -0.59
Coding 3837 96 5 2.54 ± 1.26 3.22 ± 2.28 0.57
Intron 7434 96 12 3.14 ± 1.16 1.49 ± 1.09 -1.41
5′-UTR 5526 96 26 9.16 ± 2.82 8.88 ± 4.83 -0.09
ABCB11 CA All 12759 202 34 4.53 ± 1.23 4.19 ± 2.25 -0.21
Noncoding 8796 202 26 5.02 ± 1.44 4.81 ± 2.65 -0.12
Coding 3963 202 8 3.43 ± 1.39 2.82 ± 2.04 -0.39
Intron 6078 202 15 4.19 ± 1.38 4.72 ± 2.76 0.32
5′-UTR 2718 202 11 6.88 ± 2.50 5.01 ± 3.44 -0.65
AA All 12759 94 36 5.52 ± 1.61 3.63 ± 1.61 -1.07
Noncoding 8796 94 23 5.11 ± 1.61 3.67 ± 2.11 -0.84
Coding 3963 94 13 6.41 ± 2.32 3.55 ± 2.43 -1.22
Intron 6078 94 10 3.22 ± 1.26 2.99 ± 1.26 -0.18
5′-UTR 2718 96 13 9.35 ± 3.39 3.39 ± 3.55 -1.21
JA All 12759 96 31 4.73 ± 1.41 5.28 ± 2.78 0.36
Noncoding 8796 96 21 4.65 ± 1.49 5.64 ± 1.49 0.62
Coding 3963 96 10 4.91 ± 1.92 4.48 ± 2.90 -0.23
Intron 6078 96 11 3.52 ± 1.34 3.75 ± 2.30 0.17


5′-UTR
2718
96
10
7.16 ± 2.80
9.87 ± 5.87
0.97
  • CA, Caucasian; JA, Japanese; KO, Korean; AA, African American.

  • * Number of variable sites considered for population genetic calculations. The neutral parameter (θ), nucleotide diversity (π), and Tajima's D statistic were calculated as described by Tajima (1989).