In vitro-in vivo scaling of human metabolic clearance for AZ11939714
Clint in Vitro | Scaled CL | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| HLM + NADPH | HLM + UDPGA | Hepatocytes | HLM + NADPH | HLM + UDPGA | Hepatocytes | ||||
| μl/min/mg or μl/min/106 cells | ml/min/kg | ||||||||
| 1.3 ± 0.9a | 0.36 ± 0.09 | 4 ± 4 | ≤3 | 4b | 7 | ||||
| (15) | (29) | (7) |
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↵ a Average value includes replicates below the limit of quantitation (1 μl/min/mg) which were set to this value for the mean reported here.
↵ b Modeled assuming in vivo CL = 10 × scaled CL (Soars et al., 2002).