TABLE 7

ABCB4 haplotypes and estimated haplotype frequencies

Haplotypes are aligned according to sequence similarity. Variation and the reference haplotype are given at the top with shaded coding for promoter (pale gray), intronic (light gray), synonymous (medium gray), and nonsynonymous (dark gray) polymorphic sites. Haplotypes with a frequency of ≥3% in at least one population are highlighted in bold letters. The frequencies of haplotypes that could be deduced unambiguouly from genotypes (no missing data, not more than one heterozygous variant) are marked with an asterisk. R, D, and I indicate reference nucleotide, deletion, and insertion.

TABLE 7