TABLE 1

Apparent intrinsic hepatic clearances (CLint,app) from different in vitro systems



Human

Rat
Compound Hepatocytes
Microsomes (n = 3)
Hepatocytes
Microsomes (n = 3)

Fresh (n = 4)
Cryopreserved (n = 7)
Fresh (n = 3)
Cryopreserved (n = 5)
l/h/kg l/h/kg
7-EC 1.80 1.57 7.34 2.50 2.69 16.8
Phenacetin 0.74 0.33 1.15 0.49 0.58 6.38
Propranolol 0.37 0.63 1.72 2.73 3.20 79.0
Midazolam
0.69
0.98
22.4
2.46
2.74
113