TABLE 2

Apparent clearance (l/h/kg) in freshly isolated and cryopreserved rat and human hepatocytes



Cryopreserved

Freshly Isolated
Rat Hepatocytes (n = 5)
Human Hepatocytes (n = 7)
Rat Hepatocytes (n = 3)
Human Hepatocytes (n = 4)

Mean
S.D.
%CV
Mean
S.D.
%CV
Mean
S.D.
%CV
Mean
S.D.
%CV
7-EC 2.69 0.85 31.7 1.57 0.68 43.5 2.50 0.33 13.2 1.80 1.39 77.2
Phenacetin 0.58 0.09 15.8 0.33 0.14 42.2 0.49 0.18 36.0 0.74 0.77 103
Propranolol 3.20 0.26 8.2 0.63 0.32 51.5 2.73 0.41 15.0 0.37 0.41 109
Midazolam
2.74
0.44
16.0
0.98
0.40
40.9
2.46
0.17
7.0
0.69
0.90
131