TABLE 3

Midazolam clearances (l/h/kg) and unbound fraction in microsomes and hepatocytes



Human

Rat

CLint, app
CLint
fu
CLint, app
CLint
fu
Microsomes 22.4 27.0 0.83 113 135 0.84
Hepatocytes
0.98
7.6
0.129a
2.75
36.7
0.075a
  • a Calculated from eq. 12.