Unbound parameter estimates of the final population pharmacokinetic model for oxycodone and the stability of the parameters using bootstrap resampling validation
Original Data Set | Bootstrap Resampling | |||||
|---|---|---|---|---|---|---|
| Estimate | RSE (%) | Mean | RSE (%) | |||
| CL (ml/min) | 37.4 | 3.4 | 37.6 | 3.1 | ||
| Vc (ml) | 1010 | 5 | 1016 | 4.8 | ||
| Q (ml/min) | 4.37 | 19 | 4.40 | 19 | ||
| Vper (ml) | 230 | 13 | 234 | 13 | ||
| QAV (ml/min) | 45.1 | 7.9 | 45.2 | 8.1 | ||
| fu (%) | 74.3 | 7.1 | 74.3 | 6.7 | ||
| RECblood (%)a | 65.8 | 2.3 | 65.8 | 2.4 | ||
| RECbrain (%)a | 16.4 | 6 | 16.5 | 6.1 | ||
| CLin (ml/min) | 1.91 | 20 | 1.95 | 20 | ||
| K p,uu | 3.03 | 3.8 | 3.04 | 3.7 | ||
| Interanimal Variability | ||||||
| ωCL | 0.14 | 33 | 0.14 | 34 | ||
| ωVc | 0.16 | 36 | 0.16 | 39 | ||
| ωfu | 0.28 | 51 | 0.26 | 52 | ||
| ωRECblood | 0.10 | 28 | 0.097 | 30 | ||
| ωRECbrain | 0.22 | 31 | 0.21 | 32 | ||
| Residual Variability | ||||||
| σprop,plasmab (%) | 0.195 | 9.3 | 0.189 | 9.6 | ||
| σprop,bloodb (%) | 0.171 | 8.1 | 0.169 | 8.5 | ||
| σprop,brainb (%) | 0.152 | 18 | 0.143 | 20 | ||
| σadd,brainb (mg/ml) | 0.226 | 42 | 0.224 | 43 | ||
| σadd,RECbloodc (mg/ml) | 2.44 | 12 | 2.43 | 11 | ||
| σadd,RECbrainc (mg/ml) | 2.07 | 12 | 2.03 | 12 | ||