TABLE 3

Masses of raloxifene metabolites with structural data obtained from MS/MS spectra

			RT	MS (m/z)	Δ (m/z)	MS/MS (m/z)^a
			RT	MS (m/z)	Δ (m/z)				-d	-e	ab	b	Other
			min
Metabolites with traceable ERα-affinity
RAL	Raloxifene		43.1	474		389	362	269	147	197
RM1	-OH	-OH	33.0	506	+32	ND
RM 2	Piperidine-OH	c-ring-OH	34.7	506	+32			269		363	406
RM 3	Piperidine-OH	Piperidine-OH	36.9	506	+32	389		269		470	144
RM 4	OH in a or b-ring		38.9	490	+16	405	378	285
RM 5	OH in a or b-ring		40.0	490	+16		378	285		472	418	269
RM 6	c-ring-OH		42.0	490	+16	405		269		472	389
Metabolites without traceable ERα-affinity
RM 7	Diquinone		52.0	472	-2		360	269		388

↵ a Letters correspond to those assigned to moieties in the structure of RAL in Fig. 7. The minus sign indicates the loss of the moiety in MS/MS.