Study | n | Mean CYP3A4 | Standard |
---|---|---|---|
pmol/mg | |||
Tateishi et al., 1999 | 15 | 49 | SUP |
King et al., 2002 | 22 | 33 | SUP |
Galetin et al., 2004 | 12 | 73 | SUP |
Wang et al., 2005 | 5 | 37 | SUP |
Wolbold et al., 2003 | 39 | 56 | LYMPH |
von Richter et al., 2004 | 15 | 24 | LYMPH |
Mean | 45 * | ||
Guengerich and Turvy, 1991 | 36 | 248 | PUR |
Shimada et al., 1994 | 28 | 106 | PUR |
Wandel et al., 1998 | 14 | 68 | PUR |
Lin et al., 2002 | 60 | 81 | PUR |
Lamba et al., 2002 | 53 | 80 | PUR |
Westlind-Johnsson et al., 2003 | 32 | 171 | HLMSTD |
Barter et al., in-house data | 53 | 91 | HLMSTD |
Mean | 121 * | ||
Total Weighted Mean |
|
82
|
|
PUR, purified enzyme; SUP, baculovirus-insect cells (Supersomes; BD Gentest, Woburn, MA); LYMPH, human lymphoblastoid cells (BD Gentest); YEAST, Saccharomyces cerevisiae; HLMSTD, a sample of human liver microsomes quantified for total CYP3A4 protein (Westlind-Johnsson et al., 2003).
↵* Significant difference (P < 0.01).