TABLE 3

Plasma and tissue concentrations and tissue/plasma concentration ratios of simvastatin after a 3.0 mg/kg s.c. administration to mdrl a/b KO and WT mice

Concentrations in plasma, liver, and brain at 0, 0.5, 1.5, and 3 h postdose that are not shown in the table were below the lower limit of quantitation (LLOQ) (acid/lactone): 10/10 ng/ml in plasma, 10/10 ng/ml in brain homogenate, and 40/40 ng/ml in liver homogenate. Data are means ± S.D.

Form Dosed	Form Measured	Matrix	Time	KO			WT
Form Dosed	Form Measured	Matrix	Time					Conc.	Tissue/Plasma Ratio	Conc.	Tissue/Plasma Ratio
			h	ng/ml		ng/ml
Lactone	Lactone	Plasma	0.5	18 ± 10		37 ± 25
		Brain	0.5	191 ± 33^*	13 ± 6^*	43 ± 46	0.98 ± 0.65
	Acid	Plasma	0.5	118 ± 18		135 ± 34
		Plasma	1.5	69 ± 21		112 ± 32
Acid	Acid	Plasma	0.5	120 ± 33		144 ± 23
		Plasma	1.5	48 ± 9		56 ± 5
		Plasma	3	20 ± 0		36 ± 22
		Liver	0.5	2520 ± 915	23 ± 14	1317 ± 170	9.8 ± 2.0

↵* p < 0.05.